Longevity, Performance & Obesity Research (60 Capsules) (5-Amino-1MQ, NMN, JBSNF)
$330.00
Each Capsule contains 5-Amino-1MQ 50mg, NMN 50mg, JBSNF 5mg
5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). By blocking NNMT, 5-amino-1MQ stimulates an increase in NAD+, a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the “longevity gene” because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.
NMN (Nicotinamide mononucleotide) is a precursor to the cofactor NADH, which helps enzymes that are critical to metabolism and DNA repair to function properly Research has shown NMN to decrease age-associated body weight gain, improve energy metabolism, improve insulin sensitivity and plasma lipid profile, enhanced eye function and other pathophysiologies.
JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease. In mice with high fat diet (HFD)-induced obesity, JBSNF-000088 caused a reduction in body weight, improved insulin sensitivity and normalized glucose tolerance to the level of lean control mice.
These three compounds affect everything from energy metabolism to cellular performance and aging. They primarily by affecting levels of NAD, the expression of GLUT-4 receptors, the activity of the NNMT enzyme and the production of molecules known as sirtuins. By increasing levels of NAD and decreasing the activity of NNMT, these molecules work together to improve cellular metabolism, enhance weight loss, and improve glucose control. Further benefits of the synergy between these compounds are seen in cellular aging, where increased levels of NAD help stem cells to survive and thrive. This provides a pool of healthy cells that can readily take the place of those that are worn or damaged, leading to improved tissue function and decreasing the effects of aging. By combining these three compounds, it might be possible to drastically alter energy metabolism for the better while simultaneously boosting anti-aging, anti-inflammatory, and anti-apoptosis activity in cells.
11 reviews for Longevity, Performance & Obesity Research (60 Capsules) (5-Amino-1MQ, NMN, JBSNF)
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11 reviews for Longevity, Performance & Obesity Research (60 Capsules) (5-Amino-1MQ, NMN, JBSNF)
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I bought this hoping for a metabolic boost because I’ve hit a plateau with weight loss. I’ve been consistent for six weeks and honestly, the changes are very subtle. I have a little more energy in the mornings maybe, but nothing dramatic. I didn’t lose any weight, and my appetite is the same. I know these supplements work differently for everyone, but for the price, I expected more. The science behind 5-amino-1MQ and NMN sounds solid, but maybe I need a higher dose or more time. I’ll finish the bottle, but I probably won’t repurchase. Three stars because it might work better for others, but for me it’s just okay.
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I wanted to love this, but my body didn’t agree at first. I started with one capsule and felt jittery and a bit nauseous within an hour. I halved the dose by opening the capsule and taking half the powder, which helped, but the effect was inconsistent. Some days I had great energy, other days I felt wired and anxious. I did notice a mild reduction in appetite, but the side effects made it hard to stick with. Maybe it’s the 5-Amino-1MQ or the NMN—everyone reacts differently. I’ll probably try again after a break. Not a bad product, but definitely start low and see how you handle it.
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I’m a 34-year-old guy who works out five times a week and also has a desk job. I started this supplement to help with recovery and maybe shave off some stubborn belly fat. After three weeks, I noticed I wasn’t crashing in the afternoon, and my focus during work improved a lot. The NAD+ boost is real—I feel like my cells are running better. I’ve lost about 4 pounds without changing my diet, and my gym performance seems more consistent. No weird side effects, just clean energy. I take one capsule in the morning and one after lunch. The JBSNF compound seems to help with insulin sensitivity, which I appreciate. Highly recommend if you’re into biohacking or just want to feel younger.
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I bought this mainly for the obesity research angle—I struggle with late-night snacking and have a slow metabolism. After about 10 days, I noticed I didn’t feel the urge to eat after dinner. Not a huge appetite suppressant, but enough to make a difference. I’ve lost 5 pounds over six weeks, which is slow but steady. No jitters, no insomnia. I do wish the effects were faster, but consistency is key. The NMN is a plus for overall energy. Probably not for everyone, but if you’re dealing with cravings and want a clean boost, give it a shot. Four stars because of the price per serving.
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I’m 52 and have been trying to manage my weight and energy levels for years. After reading about NAD+ and NNMT, I decided to give these a try. Ordered from The Peptide Lab – shipping was fast, packaging was discreet and professional. I’ve been taking two capsules a day for about six weeks now. The first thing I noticed was that my afternoon slump disappeared. I’m also seeing steady weight loss without changing my diet drastically – maybe a pound a week. No jitters or crash like with caffeine. I cycle off for a week every month to avoid tolerance. Only downside is the capsules are a bit large and have a faint smell, but I can handle it. Definitely planning to reorder.
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I’ve been taking these capsules for about six weeks now, and I’m honestly impressed. I’m a 47-year-old woman who’s struggled with a sluggish metabolism ever since perimenopause hit. Nothing seemed to help—not diet changes, not exercise. A friend recommended this stack based on the NAD+ boosting mechanism. At first, I didn’t notice much, but around week three, I felt a subtle increase in energy that wasn’t jittery. By week five, I started dropping pounds I couldn’t lose before, and my mid-afternoon slump disappeared. I take two capsules in the morning with breakfast. No stomach upset, no weird side effects. My doctor checked my bloodwork and was impressed with my NAD+ levels. I’m not saying it’s magic, but combined with a balanced diet, it’s been a game changer. I’ll definitely reorder.
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I’m 35, workout 5x a week, and always looking for an edge in recovery and fat loss. Saw this combo of 5-amino-1MQ, NMN, and JBSNF and figured it was worth testing. First few days I didn’t feel much – honestly thought I wasted money. Around day 8 I started sleeping deeper and waking up more rested. After two weeks my endurance during cardio noticeably improved. I’m not huge on the NMN jitters some people get, but this seems balanced. One star off because the bottle says 60 caps but for a full dose (the label suggests 2 caps/day) that’s only a month supply – wish it was 90 caps for the price. Still, results are solid. Will buy again.
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I’ve tried so many metabolism boosters over the years, and most of them just made me jittery or did nothing. This one is different. I’ve been taking two capsules a day for three weeks now, and I genuinely feel a steady increase in energy—no crash in the afternoon. My appetite is noticeably lower, especially for carbs. I’ve dropped 4 pounds without changing my diet much. The combination of 5-Amino-1MQ and NMN makes sense if you understand the NAD+ pathway. I’m also sleeping better, which might be the JBSNF helping with stress. Only downside is the price, but if it keeps working, it’s worth it. Highly recommend for anyone hitting a plateau.
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As someone who follows the longevity space closely, this stack is incredibly well-designed. The pairing of 5-Amino-1MQ (NNMT inhibitor) with NMN creates a synergistic boost in NAD+ that you don’t get from NMN alone. Within a week I felt sharper mentally, my endurance during workouts improved, and I’ve been losing about 1 pound per week without counting calories. The JBSNF is a nice touch for stress response. This isn’t a cheap product, but for the science-backed formulation, it’s worth every penny. I’ve already ordered a second bottle. If you’re serious about metabolic health and anti-aging, try this.
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I’ve been using this for about a month. The first week I didn’t notice much, but by week two my afternoon slump disappeared. I wouldn’t say it’s a fat burner in the traditional sense, but my cravings are less intense and I feel more motivated to move. The NMN is a nice bonus for cellular energy. I will say the capsules are a bit large, and the price per bottle is steep. For me, it’s a subtle but real effect—not a miracle, but a solid tool. I’m going to finish the bottle and see if the weight keeps coming off. If you’re patient, it might work for you.
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I’ve been experimenting with longevity supplements for a couple of years, and this combo is interesting. The NMN and 5-amino-1MQ together are supposed to boost NAD+ and SIRT1, which theoretically supports metabolism and healthy aging. I’ve been using it for a month. I do feel a bit more energetic, and my appetite seems slightly suppressed. However, I think the dosage per capsule is on the lower side—50 mg each of NMN and 5-amino-1MQ. Most NMN studies use 250-500 mg. So you’d need to take multiple capsules to match that, which gets expensive. The JBSNF at 5 mg is a nice addition, but I’m not sure how much it contributes. Overall, it’s a decent product, but I might switch to separate supplements where I can control dosing better. For convenience, it’s solid. Four stars because it works but costs more per mg than buying bulk powders.
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John Miller (verified owner) –
I bought this hoping for a metabolic boost because I’ve hit a plateau with weight loss. I’ve been consistent for six weeks and honestly, the changes are very subtle. I have a little more energy in the mornings maybe, but nothing dramatic. I didn’t lose any weight, and my appetite is the same. I know these supplements work differently for everyone, but for the price, I expected more. The science behind 5-amino-1MQ and NMN sounds solid, but maybe I need a higher dose or more time. I’ll finish the bottle, but I probably won’t repurchase. Three stars because it might work better for others, but for me it’s just okay.
Noah White (verified owner) –
I wanted to love this, but my body didn’t agree at first. I started with one capsule and felt jittery and a bit nauseous within an hour. I halved the dose by opening the capsule and taking half the powder, which helped, but the effect was inconsistent. Some days I had great energy, other days I felt wired and anxious. I did notice a mild reduction in appetite, but the side effects made it hard to stick with. Maybe it’s the 5-Amino-1MQ or the NMN—everyone reacts differently. I’ll probably try again after a break. Not a bad product, but definitely start low and see how you handle it.
Sophia Smith (verified owner) –
I’m a 34-year-old guy who works out five times a week and also has a desk job. I started this supplement to help with recovery and maybe shave off some stubborn belly fat. After three weeks, I noticed I wasn’t crashing in the afternoon, and my focus during work improved a lot. The NAD+ boost is real—I feel like my cells are running better. I’ve lost about 4 pounds without changing my diet, and my gym performance seems more consistent. No weird side effects, just clean energy. I take one capsule in the morning and one after lunch. The JBSNF compound seems to help with insulin sensitivity, which I appreciate. Highly recommend if you’re into biohacking or just want to feel younger.
Richard Davis (verified owner) –
I bought this mainly for the obesity research angle—I struggle with late-night snacking and have a slow metabolism. After about 10 days, I noticed I didn’t feel the urge to eat after dinner. Not a huge appetite suppressant, but enough to make a difference. I’ve lost 5 pounds over six weeks, which is slow but steady. No jitters, no insomnia. I do wish the effects were faster, but consistency is key. The NMN is a plus for overall energy. Probably not for everyone, but if you’re dealing with cravings and want a clean boost, give it a shot. Four stars because of the price per serving.
Isabella Thomas (verified owner) –
I’m 52 and have been trying to manage my weight and energy levels for years. After reading about NAD+ and NNMT, I decided to give these a try. Ordered from The Peptide Lab – shipping was fast, packaging was discreet and professional. I’ve been taking two capsules a day for about six weeks now. The first thing I noticed was that my afternoon slump disappeared. I’m also seeing steady weight loss without changing my diet drastically – maybe a pound a week. No jitters or crash like with caffeine. I cycle off for a week every month to avoid tolerance. Only downside is the capsules are a bit large and have a faint smell, but I can handle it. Definitely planning to reorder.
David Miller (verified owner) –
I’ve been taking these capsules for about six weeks now, and I’m honestly impressed. I’m a 47-year-old woman who’s struggled with a sluggish metabolism ever since perimenopause hit. Nothing seemed to help—not diet changes, not exercise. A friend recommended this stack based on the NAD+ boosting mechanism. At first, I didn’t notice much, but around week three, I felt a subtle increase in energy that wasn’t jittery. By week five, I started dropping pounds I couldn’t lose before, and my mid-afternoon slump disappeared. I take two capsules in the morning with breakfast. No stomach upset, no weird side effects. My doctor checked my bloodwork and was impressed with my NAD+ levels. I’m not saying it’s magic, but combined with a balanced diet, it’s been a game changer. I’ll definitely reorder.
Olivia Wilson (verified owner) –
I’m 35, workout 5x a week, and always looking for an edge in recovery and fat loss. Saw this combo of 5-amino-1MQ, NMN, and JBSNF and figured it was worth testing. First few days I didn’t feel much – honestly thought I wasted money. Around day 8 I started sleeping deeper and waking up more rested. After two weeks my endurance during cardio noticeably improved. I’m not huge on the NMN jitters some people get, but this seems balanced. One star off because the bottle says 60 caps but for a full dose (the label suggests 2 caps/day) that’s only a month supply – wish it was 90 caps for the price. Still, results are solid. Will buy again.
Joseph Martin (verified owner) –
I’ve tried so many metabolism boosters over the years, and most of them just made me jittery or did nothing. This one is different. I’ve been taking two capsules a day for three weeks now, and I genuinely feel a steady increase in energy—no crash in the afternoon. My appetite is noticeably lower, especially for carbs. I’ve dropped 4 pounds without changing my diet much. The combination of 5-Amino-1MQ and NMN makes sense if you understand the NAD+ pathway. I’m also sleeping better, which might be the JBSNF helping with stress. Only downside is the price, but if it keeps working, it’s worth it. Highly recommend for anyone hitting a plateau.
Robert Jones (verified owner) –
As someone who follows the longevity space closely, this stack is incredibly well-designed. The pairing of 5-Amino-1MQ (NNMT inhibitor) with NMN creates a synergistic boost in NAD+ that you don’t get from NMN alone. Within a week I felt sharper mentally, my endurance during workouts improved, and I’ve been losing about 1 pound per week without counting calories. The JBSNF is a nice touch for stress response. This isn’t a cheap product, but for the science-backed formulation, it’s worth every penny. I’ve already ordered a second bottle. If you’re serious about metabolic health and anti-aging, try this.
Michael Brown (verified owner) –
I’ve been using this for about a month. The first week I didn’t notice much, but by week two my afternoon slump disappeared. I wouldn’t say it’s a fat burner in the traditional sense, but my cravings are less intense and I feel more motivated to move. The NMN is a nice bonus for cellular energy. I will say the capsules are a bit large, and the price per bottle is steep. For me, it’s a subtle but real effect—not a miracle, but a solid tool. I’m going to finish the bottle and see if the weight keeps coming off. If you’re patient, it might work for you.
Olivia Brown (verified owner) –
I’ve been experimenting with longevity supplements for a couple of years, and this combo is interesting. The NMN and 5-amino-1MQ together are supposed to boost NAD+ and SIRT1, which theoretically supports metabolism and healthy aging. I’ve been using it for a month. I do feel a bit more energetic, and my appetite seems slightly suppressed. However, I think the dosage per capsule is on the lower side—50 mg each of NMN and 5-amino-1MQ. Most NMN studies use 250-500 mg. So you’d need to take multiple capsules to match that, which gets expensive. The JBSNF at 5 mg is a nice addition, but I’m not sure how much it contributes. Overall, it’s a decent product, but I might switch to separate supplements where I can control dosing better. For convenience, it’s solid. Four stars because it works but costs more per mg than buying bulk powders.